Emerging role of IL-23/IL-17 axis inH pylori-associated pathology

The Role of IL-23/IL-17 Axis in Lupus

Autoimmune Mechanisms of Psoriasis: Pathogenic Role of the IL-23/IL-17 Axis

Psoriasis is a chronic, recurrent, immuno-inflammatory disease of the skin and joints associated with significant morbidity and mortality. Psoriasis affects approximately 2-4% of the Caucasian population worldwide. The precise immuno-inflammatory mechanisms leading to skin psoriasis are still to be fully defined. There is emerging evidence supporting the existence of a relationship between chan...

The role of IL-23/IL-17 axis in lupus nephritis.

T cells that express IL-17 infiltrate the kidneys of patients with systemic lupus erythematosus. A significant proportion of these cells are CD3(+)CD4(-)CD8(-) double-negative T cells. In this study, we show that double-negative T cells from MRL/lpr mice express high amounts of IL-17 and that as disease progressively worsens, the expression of IL-17 and of IL-23 receptor in lymphocytes from the...

The IL-23/IL-17 axis in inflammation.

IL-23 induces the differentiation of naive CD4(+) T cells into highly pathogenic helper T cells (Th17/Th(IL-17)) that produce IL-17, IL-17F, IL-6, and TNF-alpha, but not IFN-gamma and IL-4. Two studies in this issue of the JCI demonstrate that blocking IL-23 or its downstream factors IL-17 and IL-6, but not the IL-12/IFN-gamma pathways, can significantly suppress disease development in animal m...

The IL-23/IL-17 axis as a therapeutic target.

T helper (Th) cells are known to differentiate into several distinct subsets depending on their environment. The Interleukin 17 (IL-17)-producing subset Th17, which was reported and named in 2005, has been extensively analyzed because a strong association with inflammatory disorders has been suggested. The condition in which Th17 cells are differentiated, critical transcription factors, and sim...